Synthesis, Biological Activity and Docking Studies of N,n'-(3s,4s)- Bis(3,4- Disubstituted Pyrrolidine)-1-sulfonamide Derivatives as Β-gluscosidase Inhibitors
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چکیده
Starting with L-tartaric acid the chiral 3,4-disubstituted pyrrolidine analogue sulfonamide derivatives were prepared. These compounds were examined for anti-bacterial and anti-fungal activity. Further the docking studies were carried out for the model compounds from each series against β-glucosidase and the results found are moderate. The structure–activity relationships are also briefly discussed.
منابع مشابه
Synthesis, biological activity and docking studies of N,N'-(3S,4S)- bis(3,4-disubstituted pyrrolidine)-1-sulfonamide derivatives as β-gluscosidase inhibitors
www.experimentjournal.com 1254 Synthesis, biological activity and docking studies of N,N'-(3S,4S)bis(3,4-disubstituted pyrrolidine)-1-sulfonamide derivatives as β-gluscosidase inhibitors Abstract Starting with L-tartaric acid the chiral 3,4-disubstituted pyrrolidine analogue sulfonamide derivatives were prepared. These compounds were examined for anti-bacterial and anti-fungal activity. Further...
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